Nature Made Turmeric Curcumin 500 mg, Herbal Supplement for Antioxidant Support, 60 Capsules, 60 Day Supply

I have been taking Turmeric for months to help with chronic pain, and I think it is a very useful addition to my pain management routine.This brand also does NOT contain black pepper/bioperine, which was what I was looking for. Black pepper may be good sometimes for some people, but there is good evidence showing that it increases blood serum levels of other medications, including beta blockers (taken to control blood pressure and heart rate, and some of the most commonly prescribed medications), which I take. Blood serum levels dictate how much of the dose you are taking actually gets to the site of action-- the thing in your body the medication has some influence upon-- so an unintended increase in blood serum levels of your heart medication isn't good. It may have some independent benefits and increase the turmeric absorption, but it also increases the absorption of other medications which can have dangerous side effects.Here is a list of medications on which black pepper/bioperine/piperine increases the bioavailability:barbituratesbeta-carotenecoenzyme Q10 (CoQ10)curcumin (extract from turmeric)dapsoneethambutolisoniazidnalorphinephenytoinpropranololpyrazinamiderifampicinselenium (from selenomethionine)sulfadiazenetheophyllinevitamin B-6 (pyridoxine)glucose (absorption increased)amino acids (absorption increased)Turmeric is on the list, which is why adding it to turmeric/curcumin supplements makes them more effective. It is a problem when it works the same way on other medications that have more sensitive dosing (your doctor has chosen the dose he or she wants you on for a reason!). Increasing the bioavailability-- which is essentially increasing the dose-- of things like barbiturates, seizure medications, and blood pressure and heart rate lowering drugs can be very, very dangerous. You can find more information in an article here: [...]Metabolizing enzymes inhibited or induced by piperine, and a few of the substances whose bioavailability is affected by these enzymesMetabolizing Enzymes: CYP1A1, CYP1B1, CYP1B2, CYP2E1, CYP3A4Drugs: acetaminophen, alfentanyl, amiodarone, amlodipine, astemizole, atorvastatin, barbiturates, benzodiazepines, buspirone, Cafergot, caffeine, carbamazepine, cerivastatin, chlorpheniramine, chlorzoxazone, cimetidine, ciprofloxacin, cisapride, clarithromycin, cocaine, codeine, cyclosporine, dapsone, dextromethorphan, diethyl-dithiocarbamate, diltiazem, disulfiram, efavirenz, enflurane, eplerenone, erythromycin, estradiol, ethanol, felodipine, fentanyl, finasteride, fluconazole, fluvoxamine, gestodene, Gleevec, glucocorticoids, haloperidol, halothane, hydrocortisone, indinavir, irinotecan, isoflurane, isoniazid, itraconazole, ketoconazole, LAAM, lercanidipine, lidocaine, lovastatin, methadone, methoxyflurane, mibefradil, mifepristone, modafinil, nefazodone, nelfinavir, nevirapine, nifedipine, nisoldipine, nitrendipine, norfloxacin, norfluoxetine, odanestron, phenobarbital, phenytoin, pimozide, pioglitazone, progesterone, propranolol, quinidine, quinine, rifabutin, rifampin, ritonavir, salmeterol, saquinavir, sevoflurane, sildenafil (Viagra), simvastatin, sirolimus, St. John’s wort, tamoxifen, taxol, terfenadine, testosterone, theophylline, trazodone, troglitazone, verapamil, vincristine, zaleplon, zolpidemTurmeric has been used for thousands of years for its medicinal properties, and is one of the few "alternative" remedies that has empirical evidence supporting its efficacy as an anti inflammatory. It can be used in place of or as an adjunct to modern medicine to treat pain. Less well studied for turmeric uses include immune system support and digestive healthcare (sort of like a pro-biotic). I've really found that it helps my joint pain and that's all I can speak to.Overall I highly recommend that anyone with regular or chronic pain try turmeric as an alternative to NSAIDS (Tylenol, Advil, ibuprofen, etc.) or as a supplement to those and other pain treatments. I find that it makes my pain medication more effective without increasing or causing new side effects, and that is really a hard thing to find. If you take ANY prescription medication or supplements that are dose dependent it is better to stay away from the black pepper/piperine/bioperine (they are all forms of the same thing), and that really includes things like tylenol. Since this is one of the few brands of turmeric that does not contain black pepper, it’s a good choice in my opinion.

Great for my application.

I love the health benefits I am using this for my service dog every single day however, the capsules are really big however, they are sealed tightly and there is no air pockets! Thank you :)

I like that the pills are not to big we can swallow easily

Good product

I think (am not a medical professional) it is delaying surgical treatment of bad knees. Take 1000 MG every day

I injured my knee this summer, and I was still limping pretty bad after a couple of months. I stasrted taking turmeric twice daily, and after three days, the inflammation had gone down. I now am taking one daily as a prophylactic dose, and it seems to help me deal better with the slings and arrows of fumblings, bumpings, and other misfortunes of life..I would recommend that you not take ANY medicine unless you need it. Turmeric is pretty innocuous; it's a food ingredient, found in such things as yellow mustard, but you probaqbly don't sit down and eat a cup of mustard daily. On the other hard, because I see noticeable results, i'm going to keep taking it in the smallest dose needed to achieve those results - which seems to be 500 mg daily.These are large capsules. If you have difficulty swakkowing them, it's OK to open them up and sprinkle the contents on your food. in India, they sprinkle it on rice (which gives rice curry that color), and I'm told it ;ools pretty on cauliflower, but I wouldn't eat that every day. There's always the standard mix it in applesauce, or stit it in cider vinegar. I have no problem swallowing it. Some people say pepper helps with absorbtion, but I don't lnow about that. I use a lot of fresh-ground pepper on what i eat, so maybr that helps me.

What’s great - Nature Made is USP certified, so you can trust you’re getting the ingredients you’re paying for. With non-certified, China-sourced supplements like Nutricost, you get a good value, but really have no idea what’s in the capsule. The only issue I have with this product is that it lacks pepperine, which is necessary for effective absorption of the curcumins.